MutationAssessor.org functional impact of protein mutations
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Postdoc Positions with Chris Sander. Postdoc Positions with Gunnar Rätsch.
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PROVEAN is useful for filtering sequence variants to identify nonsynonymous or indel variants that are predicted to be functionally important.
Entry points are searches by specific coordinate, dbSNP, or gene; or a comparison of cohorts based on populations in RVS. The first four queries are also wrapped in our REST API. Enter one or more genes and, optionally, genetic variants to search RVS. Enter a phenotype or disease name, and optionally a gene to search. Some pages require an HTML5-capable w.
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Mutation assessor .org. Functional impact of protein mutations. This server predicts the functional impact of amino-acid substitutions in proteins, such as mutations discovered in cancer or missense polymorphisms. The functional impact is assessed based on evolutionary conservation of the affected amino acid in protein homologs. The method has been validated. Dec 31, 2015. All scores for human Swiss-Prot sequences are available. MA scores rel3 swissprot full.tar.gz. Or split to parts of up to 1M records.CONTENT
This domain mutationassessor.org states the following, "Functional impact of protein mutations." Our analyzers observed that the website also said " This server predicts the functional impact of amino-acid substitutions in proteins, such as mutations discovered in cancer or missense polymorphisms." The Website also stated " The functional impact is assessed based on evolutionary conservation of the affected amino acid in protein homologs. The method has been validated. All scores for human Swiss-Prot sequences are available. MA scores rel3 swissprot full. Or split to parts of up to 1M records."VIEW OTHER DOMAINS
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The site also includes PCR and DHPLC protocols to help researchers apply ADS Biotec WAVE nucleic acid fragment analysis technology to the detection of both new and previously observed genetic variations. For more information on DHPLC and WAVE technology, please see www.
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